ABSTRACT
Oxford AstraZeneca (Covishield) vaccine is the 1st vaccine administered in Bangladesh to prevent the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The antibody response after 1st and 2nd doses of this vaccine was assessed in health care workers of Dhaka Medical College Hospital, Bangladesh. Blood sample was collected from healthcare workers (teachers, clinicians and medical staff) after 28 days of 1st vaccination and 14 days after 2nd vaccination. Quantitative post-vaccination antibody responses were measured using the chemiluminescent immunoassay, ADVIA Centaur (Siemens, Munich, Germany) SARS-CoV-2 IgG (COV2G) assay (output index was 1.00). Vaccine related antibody was found in 126 (41%) participants after 1st dose of AstraZeneca vaccine. After 2nd dose of vaccine, reactive level of antibody was found in 172 (93%) participants. Antibody responses were significantly higher in previously infected participants compared to participants who had no history of previous COVID-19 after 1st dose (51.92+or-50.85 vs 23.67+or-41.07, p=0.001) as well as 2nd dose of vaccine (64.12+or-97.76 vs 35.04+or-64.84, p=0.001). No difference in antibody response was observed among participants with or without comorbidities. Oxford AstraZeneca Covishield vaccine induces a strong immune response after two doses of vaccination.
ABSTRACT
Structural, electronic, optical, and thermal properties of undoped and metal, M (Ni, Cu, and Zn), doped cadmium iodide (CdI2) were studied using a generalized gradient approximation of density functional theory. Lattice constants found from the theoretical studies of the structure of the undoped and doped CdI2 are in good agreement with those found in the available experimental and theoretical investigations. A strong mixing of I 5p and M 3d states is found after the doping of 3d M in CdI2, which alters the bandgap from positive to negative. Among all M (Ni, Cu, and Zn), Ni doped CdI2 with a narrow negative bandgap evolve the quantum dot level. Due to interactions between the Cd 4d and M 3d states, the measured optical and thermal properties of the doped system assessed with pure CdI2 indicate unusual behaviors, which suggest that the material can be used in different nano-electronic and electrochemical applications and in biological levels such as detection of COVID-19 pathogens. © 2021 Author(s).